Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Hydrochloric Acid → 1-Chlorocarbonyl-4-piperidinopiperidine hydrochloride
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Hydrochloric Acid | HCID 313 | — |
| 반응물 | Phosgene | HCID 6371 | — |
| 반응물 | Irinotecan | HCID 60838 | — |
| 반응물 | 1,4'-Bipiperidine | HCID 78607 | — |
| 반응물 | 4-Piperidinopiperidine-1-carbonyl chloride | HCID 9813375 | — |
| 용매 | Dichloromethane | HCID 6344 | — |
| 생성물 | 1-Chlorocarbonyl-4-piperidinopiperidine hydrochloride | HCID 11637553 | — |
반응 단계
The present invention is related to a process for the preparation of [1,4′]bipiperidinyl-1′-carbonyl chloride or its hydrochloride, which is a useful intermediate e.g. in the preparation of irinotecan. The use of methylene chloride as a solvent in the reaction of 4-piperidinopiperidine with phosgene and the removal of the reaction solvent by using an additional distillation solvent to raise the distillation temperature gives [1,4′]bipiperidinyl-1′-carbonyl chloride hydrochloride in high yield and purity. The amount of dimer impurity will be less than 5%, even less than 1%.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US07662964B2 |
| 출처 데이터셋 | uspto-grants-2010_02 |
| ORD ID | ord-307a945911784462bcfbc42f9d5d1eb0 |
| 출처 메모 | uspto-grants-2010_02 |