Methyl 3-(methyl(pentyl)amino)propanoate → N-Methyl-N-pentyl-beta-alanine

HRID 1444845

반응식

HRID 1444845 반응식
C[O:2][C:3](=[O:13])[CH2:4][CH2:5][N:6]([CH3:12])[CH2:7][CH2:8][CH2:9][CH2:10][CH3:11]>O>[CH3:12][N:6]([CH2:7][CH2:8][CH2:9][CH2:10][CH3:11])[CH2:5][CH2:4][C:3]([OH:13])=[O:2]

참가 물질

3

반응물 1

HCID 16726422Methyl 3-(methyl(pentyl)amino)propanoate

생성물 1

HCID 16036977N-Methyl-N-pentyl-beta-alanine

시약·촉매·용매 1

HCID 962Water용매

실험 절차

68.8 g (367.4 mmol) N-methyl-N-pentyl-β-alanine methyl ester was hydrolyzed by refluxing with 138 ml water. Water was distilled off and 300 ml diethyl carbonate were added, followed by azeotropic distillation of diethyl carbonate/water (30 ml) to remove residual water. About 290 ml of a diethyl carbonate solution containing 63 g N-methyl-N-pentyl-β-alanine was obtained which could directly be used for the subsequent bisphosphorylation step.

후처리

  1. distillationWater was distilled off
  2. addition300 ml diethyl carbonate were added
  3. distillationfollowed by azeotropic distillation of diethyl carbonate/water (30 ml)
  4. customto remove residual water
  5. additionAbout 290 ml of a diethyl carbonate solution containing 63 g N-methyl-N-pentyl-β-alanine
  6. customwas obtained which

출처 및 근거

ORD 기록
ord-61203c1e27a947bb92be1994604cf1c6
출처 데이터셋
uspto-grants-2010_02
특허 번호
US07662990B2

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