1,3-Dibromopropane → 2-[4-(3-Bromopropoxy)phenyl]ethanol
반응식
[OH:1][C:2]1[CH:10]=[CH:9][C:5]([CH2:6][CH2:7][OH:8])=[CH:4][CH:3]=1.C(=O)([O-])[O-].[K+].[K+].[Br:17][CH2:18][CH2:19][CH2:20]Br>C(#N)C>[Br:17][CH2:18][CH2:19][CH2:20][O:1][C:2]1[CH:10]=[CH:9][C:5]([CH2:6][CH2:7][OH:8])=[CH:4][CH:3]=1참가 물질
5
반응 조건
- 온도
- 70 °C
실험 절차
To a solution of 4-hydroxyphenethyl alcohol (4.37 g, 31.0 mmol) and potassium carbonate (6.55 g, 47.0 mmol) in acetonitrile (62.0 mL) was added 1,3 dibromopropane (31.0 mL, 316 mmol). The reaction mixture was heated to 70° C. for 12 hours and then cooled to room temperature, filtered and concentrated under vacuum. The resulting oil was purified by silica gel chromatography using a mixture of 4:1 hexanes and ethyl acetate to give the title compound (6.21 g) as a white solid.
후처리
- temperaturecooled to room temperature
- filtrationfiltered
- concentrationconcentrated under vacuum
- customThe resulting oil was purified by silica gel chromatography
- additiona mixture of 4:1 hexanes and ethyl acetate
출처 및 근거
- ORD 기록
- ord-93f3d96d34ad4634b129237859851a50
- 출처 데이터셋
- uspto-grants-2010_06
- 특허 번호
- US07732441B2
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