Acetyl chloride → 6-fluoro-1-methyl-1,2,3,4-tetrahydroisoquinoline

HRID 1445022노트

반응식

[F:1][C:2]1[CH:3]=[C:4]([CH:8]=[CH:9][CH:10]=1)[CH2:5][CH2:6][NH2:7].[C:11](Cl)(=O)[CH3:12]>>[F:1][C:2]1[CH:3]=[C:4]2[C:8](=[CH:9][CH:10]=1)[CH:11]([CH3:12])[NH:7][CH2:6][CH2:5]2

참가 물질

반응물 2

HCID 6367Acetyl chloride

HCID 5339282-(3-Fluorophenyl)ethanamine

생성물 1

HCID 115138056-fluoro-1-methyl-1,2,3,4-tetrahydroisoquinoline

실험 절차

In accordance with the same procedures as in Steps 1, 2, and 3 of Preparation 21, except for using 3-fluorophenethylamine and acetyl chloride, 6-fluoro-1-methyl-1,2,3,4-tetrahydroisoquinoline was obtained. In accordance with the same procedures as in Preparation 20, the titled compound was obtained as pale yellow oil. (Yield: 55%) The product was used in the subsequent step without further purification.

후처리

customIn accordance with the same procedures as in Steps 1, 2, and 3 of Preparation 21

출처 및 근거

ORD 기록: ord-b340337746084820b4dc217b329ebe0f
출처 데이터셋: uspto-grants-2010_02
DOI: 10.6084/m9.figshare.5104873.v1
특허 번호: US07662832B2

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