Phenethylamine → 1-Cyclopropyl-1,2,3,4-tetrahydroisoquinoline

HRID 1445023노트

반응식

[CH2:1]([NH2:9])[CH2:2][C:3]1[CH:8]=[CH:7][CH:6]=[CH:5][CH:4]=1.[CH:10]1([C:13](Cl)=O)[CH2:12][CH2:11]1>>[CH:10]1([CH:13]2[C:8]3[C:3](=[CH:4][CH:5]=[CH:6][CH:7]=3)[CH2:2][CH2:1][NH:9]2)[CH2:12][CH2:11]1

참가 물질

반응물 2

HCID 1001Phenethylamine

HCID 77637Cyclopropanecarbonyl chloride

생성물 1

HCID 115573681-Cyclopropyl-1,2,3,4-tetrahydroisoquinoline

실험 절차

In accordance with the same procedures as in Steps 1, 2, and 3 of Preparation 21, except for using phenethylamine and cyclopropanecarbonyl chloride, 1-cyclopropyl-1,2,3,4-tetrahydroisoquinoline was obtained. In accordance with the same procedures as in Preparation 20, the titled compound was obtained as pale yellow oil. (Yield: 82%) The product was used in the subsequent step without further purification.

후처리

customIn accordance with the same procedures as in Steps 1, 2, and 3 of Preparation 21

출처 및 근거

ORD 기록: ord-5bf1b6bc6cc2416eb5e1deef0844b489
출처 데이터셋: uspto-grants-2010_02
DOI: 10.6084/m9.figshare.5104873.v1
특허 번호: US07662832B2

반응 노트

불러오는 중…