Water → 647833-71-4
반응식
[CH3:1][O:2][C:3]1[CH:8]=[CH:7][C:6]([C:9]([C:11]2[S:12][CH:13]=[CH:14][C:15]=2[O:16]C)=[O:10])=[CH:5][CH:4]=1.O>ClCCl>[OH:16][C:15]1[CH:14]=[CH:13][S:12][C:11]=1[C:9]([C:6]1[CH:7]=[CH:8][C:3]([O:2][CH3:1])=[CH:4][CH:5]=1)=[O:10]참가 물질
4
실험 절차
993 mg of (4-methoxy-phenyl)-(3-methoxy-thiophen-2-yl)-methanone were dissolved in 20 ml of dry dichloromethane, and 7 ml of boron tribromide/dimethyl sulfide complex were added. The mixture was stirred at room temp. until the reaction was complete (TLC check). It was then poured into water and extracted several times with dichloromethane. The organic phase was dried and concentrated, and the residue was purified by column chromatography (SiO2, ethyl acetate/n-heptane=1:4). The product with the molecular weight of 234.3 (C12H10O3S), MS (Cl): 235 (M+H+) was obtained.
후처리
- addition7 ml of boron tribromide/dimethyl sulfide complex were added
- extractionextracted several times with dichloromethane
- customThe organic phase was dried
- concentrationconcentrated
- customthe residue was purified by column chromatography (SiO2, ethyl acetate/n-heptane=1:4)
- customThe product with the molecular weight of 234.3 (C12H10O3S), MS (Cl): 235 (M+H+) was obtained
출처 및 근거
- ORD 기록
- ord-7b3c4556084e44a38e2e03868d36fbd6
- 출처 데이터셋
- uspto-grants-2010_02
- 특허 번호
- US07666848B2
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