2-chloro-6-nitroquinoxaline → 2-Methoxy-6-nitroquinoxaline
반응식
Cl[C:2]1[CH:11]=[N:10][C:9]2[C:4](=[CH:5][CH:6]=[C:7]([N+:12]([O-:14])=[O:13])[CH:8]=2)[N:3]=1.[CH3:15][O-:16].[Na+]>C1COCC1>[CH3:15][O:16][C:2]1[CH:11]=[N:10][C:9]2[C:4](=[CH:5][CH:6]=[C:7]([N+:12]([O-:14])=[O:13])[CH:8]=2)[N:3]=1참가 물질
4
실험 절차
Into 10 ml of THF was dissolved 1.16 g of 2-chloro-6-nitroquinoxaline, and then 1.0 g of sodium methoxide was added thereto, followed by heating under refluxing for 30 minutes. Then, the solvent was removed by evaporation. Water was added to the residue, followed by extraction with ethyl acetate. The organic layer was washed with saturated saline. After the solvent was removed by evaporation, the residue was crystallized from diethyl ether-hexane to obtain 776 mg of the title compound.
후처리
- temperatureby heating
- temperatureunder refluxing for 30 minutes
- customThen, the solvent was removed by evaporation
- additionWater was added to the residue
- extractionfollowed by extraction with ethyl acetate
- washThe organic layer was washed with saturated saline
- customAfter the solvent was removed by evaporation
- customthe residue was crystallized from diethyl ether-hexane
출처 및 근거
- ORD 기록
- ord-2c8ab18ae9184903844eccb33f4e62f3
- 출처 데이터셋
- uspto-grants-2010_02
- 특허 번호
- US07666873B2
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