Methylamine → 1-(3-Chloro-2-pyridinyl)-N-[2,4-dichloro-6-[(methylamino)carbonyl]phenyl]-3-[(methylsulfonyl)oxy]-1H-pyrazole-5-carboxamide
반응식
[Cl:1][C:2]1[CH:3]=[C:4]([Cl:30])[C:5]2[N:10]=[C:9]([C:11]3[N:15]([C:16]4[C:21]([Cl:22])=[CH:20][CH:19]=[CH:18][N:17]=4)[N:14]=[C:13]([O:23][S:24]([CH3:27])(=[O:26])=[O:25])[CH:12]=3)[O:8][C:7](=[O:28])[C:6]=2[CH:29]=1.[CH3:31][NH2:32]>C(#N)C>[Cl:22][C:21]1[C:16]([N:15]2[C:11]([C:9]([NH:10][C:5]3[C:6]([C:7]([NH:32][CH3:31])=[O:28])=[CH:29][C:2]([Cl:1])=[CH:3][C:4]=3[Cl:30])=[O:8])=[CH:12][C:13]([O:23][S:24]([CH3:27])(=[O:26])=[O:25])=[N:14]2)=[N:17][CH:18]=[CH:19][CH:20]=1참가 물질
4
반응물 2
생성물 1
시약·촉매·용매 1
실험 절차
To a solution of 6,8-dichloro-2-[1-(3-chloro-2-pyridinyl)-3-[(methylsulfonyl)oxy]-1H-pyrazol-5-yl]-4H-3,1-benzoxazin-4-one (i.e. the product of step D) (0.05 g, 0.10 mmol) in acetonitrile (3 mL) was added methylamine (2.0 M solution in THF, 0.5 mL, 1 mmol). The resulting solution was stirred at room temperature overnight. Thin layer chromatography showed the reaction to be incomplete. Methylamine (2.0 M solution in THF, 0.5 mL, 1 mmol) was added dropwise and the reaction stirred 1 hour at room temperature. Thin layer chromatography showed the reaction was complete. The reaction mixture was concentrated to dryness to yield 0.057 g of the title compound, a compound of present invention, as a white solid.