Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Dichloromethane → 3-[2-(4-Bromo-phenyl)-5-methyl-oxazol-4-yl]-propionaldehyde
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Dichloromethane | HCID 6344 | — |
| 반응물 | Tetrahydrofuran | HCID 8028 | — |
| 반응물 | 2-(4-Bromo-phenyl)-4-(2-[1,3]dithian-2-yl-ethyl)-5-methyl-oxazole | HCID 86096684 | — |
| 용매 | Water | HCID 962 | — |
| 생성물 | 3-[2-(4-Bromo-phenyl)-5-methyl-oxazol-4-yl]-propionaldehyde | HCID 86096686 | 86% |
반응 단계
Add HgClO4.4H2O (1.49 g, 4.00 mmol) to a solution of 2-(4-bromo-phenyl)-4-(2-[1,3]dithian-2-yl-ethyl)-5-methyl-oxazole (0.672 g, 1.75 mmol) in 1:1 THF:CH2Cl2 (16 mL) and water (1.6 mL). After 6 hours, filter and wash the solids with dichloromethane. Concentrate to give 3-[2-(4-bromo-phenyl)-5-methyl-oxazol-4-yl]-propionaldehyde (0.445 g, 86%). MS (m/e): 294 (M+1).
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US07666871B2 |
| 출처 데이터셋 | uspto-grants-2010_02 |
| ORD ID | ord-581f60603cc340ffa47786629ed187a7 |
| 출처 메모 | uspto-grants-2010_02 |