Potassium Carbonate → 3-Methyl-2-(2-methyl-1H-indol-4-yloxy)-butyric acid ethyl ester

HRID 1445889

반응식

HRID 1445889 반응식
[OH:1][C:2]1[CH:10]=[CH:9][CH:8]=[C:7]2[C:3]=1[CH:4]=[C:5]([CH3:11])[NH:6]2.[CH2:12]([O:14][C:15](=[O:21])[CH:16](Br)[CH:17]([CH3:19])[CH3:18])[CH3:13].C(=O)([O-])[O-].[K+].[K+]>CC(C)=O>[CH2:12]([O:14][C:15](=[O:21])[CH:16]([O:1][C:2]1[CH:10]=[CH:9][CH:8]=[C:7]2[C:3]=1[CH:4]=[C:5]([CH3:11])[NH:6]2)[CH:17]([CH3:19])[CH3:18])[CH3:13]

참가 물질

5

반응물 3

HCID 11430Potassium CarbonateHCID 79068Ethyl 2-bromoisovalerateHCID 5902254-Hydroxy-2-methylindole

생성물 1

HCID 591703963-Methyl-2-(2-methyl-1H-indol-4-yloxy)-butyric acid ethyl ester

시약·촉매·용매 1

HCID 180Acetone용매

실험 절차

A mixture of 4-hydroxy-2-methylindole (1) (1.5 g, 0.010 mole), 2-bromo-3-methyl-butyric acid ethyl ester (2.2 g, 0.010 mole) and potassium carbonate (excess) in acetone (50 mL) was refluxed for 3 days. The reaction mixture was filtered, and the filtrate was concentrated. The residue was purified by column chromatography (20:1 Hex:EtOAc) to afford intermediate 2. Yield: 1.88 g, 71%

후처리

  1. temperaturewas refluxed for 3 days
  2. filtrationThe reaction mixture was filtered
  3. concentrationthe filtrate was concentrated
  4. customThe residue was purified by column chromatography (20:1 Hex:EtOAc)

출처 및 근거

ORD 기록
ord-4432c8079e4c4c67bb448d3e97049ea2
출처 데이터셋
uspto-grants-2010_02
특허 번호
US07666898B2

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