(4-methoxy-1H-pyrrolo[2,3-b]pyridin-2-yl)methanol → 4-methoxy-2-methyl-1H-pyrrolo[2,3-b]pyridine
반응식
[CH3:1][O:2][C:3]1[CH:8]=[CH:7][N:6]=[C:5]2[NH:9][C:10]([CH2:12]O)=[CH:11][C:4]=12>CO.[OH-].[OH-].[Pd+2]>[CH3:1][O:2][C:3]1[CH:8]=[CH:7][N:6]=[C:5]2[NH:9][C:10]([CH3:12])=[CH:11][C:4]=12참가 물질
4
실험 절차
A suspension of (4-methoxy-1H-pyrrolo[2,3-b]pyridin-2-yl)methanol 4 (0.90 g, 5.05 mmol) and Pd(OH)2 (100 mg) in methanol containing 4N aq. HCl solution (10 mL) was hydrogenated under hydrogen pressure (50 psi) for 36 h. The acidic mixture was quenched with 1N NaOH solution. Filtration through celite, concentration and purification on silica gel column using 5% methanol in CH2Cl2 to gave 5 as pale yellow syrup. Yield: 0.68 g, 83%; ESI MS: m/z 163.01 (M+1).
후처리
- customfor 36 h
- customThe acidic mixture was quenched with 1N NaOH solution
- filtrationFiltration
- concentrationthrough celite, concentration and purification on silica gel column
출처 및 근거
- ORD 기록
- ord-5264f5d2b0c04993aad992605ec1dbed
- 출처 데이터셋
- uspto-grants-2010_02
- 특허 번호
- US07666898B2
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