Triethylamine → 1-benzyl-2-ethyl-1H-pyrrole

HRID 1445937

반응식

HRID 1445937 반응식
[C:1]1(C2C=CC=CC=2)[CH:6]=[CH:5][CH:4]=[CH:3][C:2]=1[CH2:7][N:8]1[CH:12]=[CH:11][CH:10]=[C:9]1[CH2:13][CH3:14].C1(C2C=CC=CC=2)C=CC=CC=1CN.C(N(CC)CC)C>C1C=CC=CC=1>[CH2:7]([N:8]1[CH:12]=[CH:11][CH:10]=[C:9]1[CH2:13][CH3:14])[C:2]1[CH:3]=[CH:4][CH:5]=[CH:6][CH:1]=1

참가 물질

5

반응물 3

HCID 8471TriethylamineHCID 2633661-Biphenyl-2-ylmethanamineHCID 591704071-(Biphenyl-2-ylmethyl)-2-ethyl-1h-pyrrole

생성물 1

HCID 32494221-benzyl-2-ethyl-1H-pyrrole

시약·촉매·용매 1

HCID 241Benzene용매

실험 절차

1-(biphenyl-2-ylmethyl)-2-ethyl-1H-pyrrole, 13: To the crude 12 (14 g, 83 mmol) in dry benzene (200 mL) at room temperature is added biphenyl-2-ylmethanamine solution (100 mmol) and triethylamine (110 mmol). The solution is heated to reach 65° C. and stirred for 18 h. The resulted reaction mixture is filtered and concentrated. The crude product was purified by silica gel chromatography to afford 13

후처리

  1. temperatureThe solution is heated
  2. customto reach 65° C.
  3. customThe resulted reaction mixture
  4. filtrationis filtered
  5. concentrationconcentrated
  6. customThe crude product was purified by silica gel chromatography

출처 및 근거

ORD 기록
ord-6aecf2aef7954c0e9158959462e7c8ff
출처 데이터셋
uspto-grants-2010_02
특허 번호
US07666898B2

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