2-(tert-Butylamino)ethanol → (1E,4S,4aR,5R,6aS,7S)-1-{[tert-butyl(2-hydroxyethyl)amino]methylene}-7,11-dihydroxy-4-(methoxymethyl)-4a,6a-dimethyl-2,10-dioxo-1,2,4,4a,5,6,6a,7,8,9,9a,10-dodecahydroindeno[4,5-h]isochromen-5-yl acetate

참여 물질

역할	이름	HCID	투입량
반응물	2-(tert-Butylamino)ethanol	HCID 78361	—
반응물	17beta-Hydroxy wortmannin	HCID 9867340	—
용매	Dichloromethane	HCID 6344	—
생성물	(1E,4S,4aR,5R,6aS,7S)-1-{[tert-butyl(2-hydroxyethyl)amino]methylene}-7,11-dihydroxy-4-(methoxymethyl)-4a,6a-dimethyl-2,10-dioxo-1,2,4,4a,5,6,6a,7,8,9,9a,10-dodecahydroindeno[4,5-h]isochromen-5-yl acetate	HCID 11519606	48.7%

반응 단계

To a solution of 50 mg (0.12 mmol) 17-hydroxywortmannin in 0.5 mL CH2Cl2 is added 28.1 mg (0.24 mmol) 2-(tert-butylamino)-ethanol. The reaction mixture is stirred at room temperature overnight. CH2Cl2 is removed in vacuo. The residue is triturated with diethyl ether (Et2O) to give 32 mg (48.7%) product as an orange powder. MS (ESI) m/z 548.3 (M+1).

출처 및 근거

DOI	10.6084/m9.figshare.5104873.v1
특허 번호	US07666901B2
출처 데이터셋	uspto-grants-2010_02
ORD ID	ord-c7ffb7f56b914ec7a230738caf7e665d
출처 메모	uspto-grants-2010_02