N,1-dimethylpyrrolidin-3-amine → (1e,4s,4Ar,5r,6as,7s)-7,11-dihydroxy-4-(methoxymethyl)-4a,6a-dimethyl-1-{[methyl(1-methylpyrrolidin-3-yl)amino]methylene}-2,10-dioxo-1,2,4,4a,5,6,6a,7,8,9,9a,10-dodecahydroindeno[4,5-h]isochromen-5-yl acetate

HRID 1445981노트

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HRID 1445981 반응식
[CH3:1][C:2]([O:4][C@H:5]1[C:14]2[C@@:15]3([CH3:30])[C@@H:26]([CH2:27][O:28][CH3:29])[O:25][C:23](=[O:24])[C:17]4=[CH:18][O:19][C:20]([C:21](=[O:22])[C:13]=2[C@@H:8]2[CH2:9][CH2:10][C@H:11]([OH:12])[C@@:7]2([CH3:31])[CH2:6]1)=[C:16]34)=[O:3].[CH3:32][NH:33][CH:34]1[CH2:38][N:37]([CH3:39])[CH2:36][CH2:35]1>C(Cl)Cl>[C:2]([O:4][C@H:5]1[C:14]2[C@:15]3([CH3:30])[C:16](/[C:17](=[CH:18]\[N:33]([CH3:32])[CH:34]4[CH2:35][CH2:36][N:37]([CH3:39])[CH2:38]4)/[C:23](=[O:24])[O:25][C@@H:26]3[CH2:27][O:28][CH3:29])=[C:20]([OH:19])[C:21](=[O:22])[C:13]=2[CH:8]2[C@@:7]([CH3:31])([C@@H:11]([OH:12])[CH2:10][CH2:9]2)[CH2:6]1)(=[O:3])[CH3:1]

참가 물질

4

반응물 2

HCID 2758520N,1-dimethylpyrrolidin-3-amineHCID 986734017beta-Hydroxy wortmannin

생성물 1

HCID 11512258(1e,4s,4Ar,5r,6as,7s)-7,11-dihydroxy-4-(methoxymethyl)-4a,6a-dimethyl-1-{[methyl(1-methylpyrrolidin-3-yl)amino]methylene}-2,10-dioxo-1,2,4,4a,5,6,6a,7,8,9,9a,10-dodecahydroindeno[4,5-h]isochromen-5-yl acetate수율 38.3%

시약·촉매·용매 1

HCID 6344Dichloromethane용매

실험 절차

To a solution of 50 mg (0.12 mmol) 17-hydroxywortmannin in 0.5 mL CH2Cl2 is added 27.4 mg (0.24 mmol) N,N′-dimethyl-3-aminopyrrolidine. The reaction mixture is stirred at room temperature overnight. CH2Cl2 is removed in vacuo. The residue is triturated with Et2O to give 25 mg (38%) product as an orange powder.

후처리

  1. customCH2Cl2 is removed in vacuo
  2. customThe residue is triturated with Et2O

출처 및 근거

ORD 기록
ord-e0c3e1d909184f1f902433fe0c7071c5
출처 데이터셋
uspto-grants-2010_02
특허 번호
US07666901B2

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