Methyl(3-(4-methylpiperazin-1-yl)propyl)amine → HCID 68542076, 화합물

HRID 1445998노트

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HRID 1445998 반응식
[CH3:1][C:2]([O:4][C@H:5]1[C:14]2[C@@:15]3([CH3:30])[C@@H:26]([CH2:27][O:28][CH3:29])[O:25][C:23](=[O:24])[C:17]4=[CH:18][O:19][C:20]([C:21](=[O:22])[C:13]=2[C@@H:8]2[CH2:9][CH2:10][C@H:11]([OH:12])[C@@:7]2([CH3:31])[CH2:6]1)=[C:16]34)=[O:3].[CH3:32][NH:33][CH2:34][CH2:35][CH2:36][N:37]1[CH2:42][CH2:41][N:40]([CH3:43])[CH2:39][CH2:38]1>C(Cl)Cl>[OH:19][C:20]1[C:21](=[O:22])[C:13]2[CH:8]3[C:7]([CH3:31])([CH:11]([OH:12])[CH2:10][CH2:9]3)[CH2:6][CH:5]([O:4][C:2](=[O:3])[CH3:1])[C:14]=2[C:15]2([CH3:30])[C:16]=1[C:17](=[CH:18][N:33]([CH3:32])[CH2:34][CH2:35][CH2:36][N:37]1[CH2:38][CH2:39][N:40]([CH3:43])[CH2:41][CH2:42]1)[C:23](=[O:24])[O:25][CH:26]2[CH2:27][O:28][CH3:29]

참가 물질

4

반응물 2

HCID 7219854Methyl(3-(4-methylpiperazin-1-yl)propyl)amineHCID 986734017beta-Hydroxy wortmannin

생성물 1

HCID 68542076HCID 68542076, 화합물

시약·촉매·용매 1

HCID 6344Dichloromethane용매

실험 절차

To a solution of 100 mg (0.23 mmol) 17-hydroxywortmannin in 2 mL CH2Cl2 is added methyl-[3-(4-methyl-piperazine-1-yl)propyl]amine (80 mg, 0.46 mmol). The reaction mixture is stirred at room temperature for 12 hours and then concentrated in vacuo. The residue is dissolved in EtOAc and precipitated with hexane. The precipitate is washed two times with hexane to give the product as a yellow solid. MS (ESI) m/z 603 (M+H).

후처리

  1. concentrationconcentrated in vacuo
  2. dissolutionThe residue is dissolved in EtOAc
  3. customprecipitated with hexane
  4. washThe precipitate is washed two times with hexane

출처 및 근거

ORD 기록
ord-6903463a6c3d49c38d2fa0c9da7d1e2b
출처 데이터셋
uspto-grants-2010_02
특허 번호
US07666901B2

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