Dimethylamine → 1,2-Ethanediamine,N2-(1,1-dimethylethyl)-N1,N1-dimethyl-

HRID 1446024노트

반응식

HRID 1446024 반응식
Cl.[C:2]([NH:6][CH2:7][CH2:8]Cl)([CH3:5])([CH3:4])[CH3:3].C(=O)([O-])[O-].[K+].[K+].[CH3:16][NH:17][CH3:18]>>[C:2]([NH:6][CH2:7][CH2:8][N:17]([CH3:18])[CH3:16])([CH3:5])([CH3:4])[CH3:3]

참가 물질

4

반응물 3

HCID 674DimethylamineHCID 11430Potassium CarbonateHCID 25021339HCID 25021339, 화합물

생성물 1

HCID 206267161,2-Ethanediamine,N2-(1,1-dimethylethyl)-N1,N1-dimethyl-수율 56%

반응 조건

온도
140 °C

실험 절차

2-(t-Butylamino)ethylchloride hydrochloride (1.2 g, 7.0 mmol) is dissolved in aqueous dimethylamine solution (40% by weight, 22 mL) in a sealed tube. The mixture is heated in a 140° C. oil bath for six hours, allowed to cool to room temperature, and then is saturated with solid potassium carbonate. The mixture is extracted thrice with ethyl acetate. The combined extracts are dried over anhydrous sodium sulfate, decanted, and concentrated under reduced pressure to give N-t-butyl,N′,N′-dimethylethylenediamine as a light brown liquid (0.57 g, 56%). The crude material is carried on to the following step without further purification.

후처리

  1. temperatureto cool to room temperature
  2. extractionThe mixture is extracted thrice with ethyl acetate
  3. dry with materialThe combined extracts are dried over anhydrous sodium sulfate
  4. customdecanted
  5. concentrationconcentrated under reduced pressure

출처 및 근거

ORD 기록
ord-40f60a6a7aa94965977c1c9486393b81
출처 데이터셋
uspto-grants-2010_02
특허 번호
US07666901B2

반응 노트

불러오는 중…