1-(2-Fluoro-4-nitrophenyl)-2-pyrrolidinone → 1-(4-Amino-2-fluorophenyl)pyrrolidin-2-one
반응식
[F:1][C:2]1[CH:7]=[C:6]([N+:8]([O-])=O)[CH:5]=[CH:4][C:3]=1[N:11]1[CH2:15][CH2:14][CH2:13][C:12]1=[O:16]>CO.C1COCC1.[Pd]>[NH2:8][C:6]1[CH:5]=[CH:4][C:3]([N:11]2[CH2:15][CH2:14][CH2:13][C:12]2=[O:16])=[C:2]([F:1])[CH:7]=1참가 물질
4
실험 절차
650 mg (2.9 mmol) of 1-(2-fluoro-4-nitro-phenyl)-pyrrolidin-2-one (Example 14b) and 65 mg of Pd/C 10% are shacked in 15 ml of MeOH/THF (1:1) under 1.1 bar of H2 for 2 h at rt. After completion of the reaction, the catalyst is filtered-off and the filtrate is evaporated in vacuo to give the title compound as an off-white solid. ES-MS: 195 (M+H)+; analytical HPLC: tret=1.91 minutes (Grad 1).
후처리
- customAfter completion of the reaction
- customthe filtrate is evaporated in vacuo
출처 및 근거
- ORD 기록
- ord-72531754b3e849f496fea5188e4359ad
- 출처 데이터셋
- uspto-grants-2010_02
- 특허 번호
- US07667039B2
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