참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|
| 반응물 | Water | HCID 962 | — |
| 반응물 | Sodium Bicarbonate | HCID 516892 | — |
| 반응물 | [3-Chloro-4-(4-methyl-piperazin-1-yl)-phenyl]carbamic acid tert-butyl ester | HCID 66870439 | — |
| 용매 | Hydrochloric Acid | HCID 313 | — |
| 용매 | 1,4-Dioxane | HCID 31275 | — |
| 생성물 | 3-Chloro-4-(4-methylpiperazin-1-yl)aniline | HCID 820343 | — |
반응 단계
298 mg (0.92 mmol) of [3-chloro-4-(4-methyl-piperazin-1-yl)-phenyl]-carbamic acid tert-butyl ester (Example 65b) are dissolved in 5 ml of 4 N HCl in dioxane. The solution is stirred for 4 h at 50° C., and after this time water is added and the pH is adjusted to 8 with NaHCO3. The suspension is extracted with n-butanol. The organic phase is washed with water, dried over MgSO4 and evaporated to dryness to provide the title compound. Title compound: ES-MS: 226.2 (M+H)+; analytical HPLC: tret=3.09 minutes (Grad 2).
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| 특허 번호 | US07667039B2 |
|---|
| 출처 데이터셋 | uspto-grants-2010_02 |
|---|
| ORD ID | ord-8367b4a467d5473790936fe5a44be2f8 |
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| 출처 메모 | uspto-grants-2010_02 |
|---|
