Pyrazole → 4-(1H-Pyrazol-1-yl)aniline

반응식

F[C:2]1[CH:7]=[CH:6][C:5]([N+:8]([O-])=O)=[CH:4][CH:3]=1.[NH:11]1[CH:15]=[CH:14][CH:13]=[N:12]1>>[N:11]1([C:2]2[CH:7]=[CH:6][C:5]([NH2:8])=[CH:4][CH:3]=2)[CH:15]=[CH:14][CH:13]=[N:12]1

참가 물질

반응물 2

HCID 1048Pyrazole

HCID 9590p-Fluoronitrobenzene

생성물 1

HCID 5942744-(1H-Pyrazol-1-yl)aniline

실험 절차

The title compound is obtained as described in Example 18a/b using 1-fluoro-4-nitro-benzene (Fluka, Buchs, Switzerland) and 1H-pyrazole (Fluka, Buchs, Switzerland). Title compound: ES-MS: 160.2 (M+H)+; analytical HPLC: tret=3.61 minutes (Grad 2).

출처 및 근거

ORD 기록: ord-898bff64fee34ff58ff166c89f67afd7
출처 데이터셋: uspto-grants-2010_02
DOI: 10.6084/m9.figshare.5104873.v1
특허 번호: US07667039B2

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