HCID 17749752, 화합물 → 5-(2-Chlorophenyl)-4-{[3-(2-chlorophenyl)pyrrolidin-1-yl]carbonyl}isoxazole

HRID 1446228노트

반응식

HRID 1446228 반응식
[Cl:1][C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][C:3]=1[C:8]1[O:12][N:11]=[CH:10][C:9]=1[C:13]([OH:15])=O.C(O)(=O)C(O)=O.[Cl:22][C:23]1[CH:28]=[CH:27][CH:26]=[CH:25][C:24]=1[CH:29]1[CH2:33][CH2:32][NH:31][CH2:30]1>>[Cl:1][C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][C:3]=1[C:8]1[O:12][N:11]=[CH:10][C:9]=1[C:13]([N:31]1[CH2:32][CH2:33][CH:29]([C:24]2[CH:25]=[CH:26][CH:27]=[CH:28][C:23]=2[Cl:22])[CH2:30]1)=[O:15]

참가 물질

3

반응물 2

HCID 17749752HCID 17749752, 화합물HCID 224942765-(2-Chlorophenyl)-1,2-oxazole-4-carboxylic acid

생성물 1

HCID 591701615-(2-Chlorophenyl)-4-{[3-(2-chlorophenyl)pyrrolidin-1-yl]carbonyl}isoxazole

실험 절차

The title compound was prepared from 5-(2-chlorophenyl)isoxazole-4-carboxylic acid (11.2 mg, 0.050 mmol) and 3-(2-chlorophenyl)pyrrolidine oxalate (16.3 mg, 0.060 mmol) as described in synthetic method C and thereafter purified by preparative HPLC method B to give a solid (4.0 mg). MS (pos) m/z 387.0 (M+H).

후처리

  1. custompurified by preparative HPLC method B

출처 및 근거

ORD 기록
ord-e103675ef2654f74810d127d07f4ce42
출처 데이터셋
uspto-grants-2010_02
특허 번호
US07666888B2

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