Diisopropylethylamine → ((4R)-1-{[5-(4-methylphenyl)isoxazol-4-yl]carbonyl}-4-phenylpyrrolidin-3-yl)methanol

참여 물질

역할	이름	HCID	투입량
반응물	Diisopropylethylamine	HCID 81531	—
반응물	O-(Benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate	HCID 2733207	—
반응물	(4-Phenylpyrrolidin-3-yl)methanol	HCID 13316928	—
반응물	5-(p-Tolyl)isoxazole-4-carboxylic acid	HCID 22831706	—
용매	Dimethylformamide	HCID 6228	—
생성물	((4R)-1-{[5-(4-methylphenyl)isoxazol-4-yl]carbonyl}-4-phenylpyrrolidin-3-yl)methanol	HCID 68684409	33.4%

반응 단계

A solution of (4-phenylpyrrolidin-3-yl)methanol (7 mg, 0.033 mmol), TBTU (13 mg, 0.039 mmol, 1.2 equ.) and N-ethyl-N-isopropylpropan-2-amine (11 μL, 0.066 mmol, 2 equ.) in DMF (0.3 mL) was added to 5-(4-methylphenyl)isoxazole-4-carboxylic acid (7 mg, 0.033 mmol) and the reaction mixture was stirred at rt for 2 h. The solvent was evaporated and the crude product was purified by RP-HPLC. After evaporation of the solvents the product was dried in vacuum to yield the title compound (4 mg). MS (ESI, pos. ion) m/z calcd for C22H22N2O3: 362.1630, found 362.1629.

출처 및 근거

DOI	10.6084/m9.figshare.5104873.v1
특허 번호	US07666888B2
출처 데이터셋	uspto-grants-2010_02
ORD ID	ord-de973918f5334992b12fc13abd8e2201
출처 메모	uspto-grants-2010_02