Tetrahydrofuran → 5-Methyl-3-phenylhexan-2-one
반응식
CON(C)[C:4](=[O:16])[CH:5]([C:10]1[CH:15]=[CH:14][CH:13]=[CH:12][CH:11]=1)[CH2:6][CH:7]([CH3:9])[CH3:8].[CH2:18]1COCC1>C[Mg]Br>[CH3:8][CH:7]([CH3:9])[CH2:6][CH:5]([C:10]1[CH:15]=[CH:14][CH:13]=[CH:12][CH:11]=1)[C:4](=[O:16])[CH3:18]참가 물질
4
실험 절차
To a solution of 75 mg (0.317 mmol) N-methoxy-N-methyl-4-methyl-2-phenylpentanamide in 1 mL dry THF, 0.45 mL 1.4 M methylmagnesium bromide was added. The reaction was stirred for 1 h, quenched with 1.2 N HCl and extracted with EtOAc. The EtOAc solution was washed with brine, dried and concentrated leaving the title compound. 1H NMR: (500 MHz, CDCl3): δ 0.95 (2d, 6H), 1.42 (m, 1H), 1.67 (m, 1H), 1.9 (m, 1H), 2.06 (s, 3H), 3.73 (m, 1H), 7.0-7.4 (m, 5H).
후처리
- customquenched with 1.2 N HCl
- extractionextracted with EtOAc
- washThe EtOAc solution was washed with brine
- customdried
- concentrationconcentrated
출처 및 근거
- ORD 기록
- ord-a6e221b684224455a995b2eda93a3be5
- 출처 데이터셋
- uspto-grants-2010_02
- 특허 번호
- US07667053B2
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