Diethylamine → 3,6-Bis(4-diethylaminobutoxy)acridine trihydrochloride

HRID 1446922노트

반응식

HRID 1446922 반응식
[ClH:1].[Cl:2][CH2:3][CH2:4][CH2:5][CH2:6][O:7][C:8]1[CH:9]=[CH:10][C:11]2[C:20]([CH:21]=1)=[N:19][C:18]1[C:13](=[CH:14][CH:15]=[C:16]([O:22][CH2:23][CH2:24][CH2:25][CH2:26]Cl)[CH:17]=1)[CH:12]=2.[CH2:28]([NH:30][CH2:31][CH3:32])[CH3:29]>>[ClH:2].[ClH:1].[ClH:2].[CH2:28]([N:30]([CH2:31][CH3:32])[CH2:3][CH2:4][CH2:5][CH2:6][O:7][C:8]1[CH:9]=[CH:10][C:11]2[C:20]([CH:21]=1)=[N:19][C:18]1[C:13](=[CH:14][CH:15]=[C:16]([O:22][CH2:23][CH2:24][CH2:25][CH2:26][N:19]([CH2:20][CH3:11])[CH2:18][CH3:17])[CH:17]=1)[CH:12]=2)[CH3:29]

참가 물질

3

반응물 2

HCID 8021DiethylamineHCID 205534713,6-Bis(4-chlorobutoxy)acridine hydrochloride

생성물 1

HCID 205535013,6-Bis(4-diethylaminobutoxy)acridine trihydrochloride

실험 절차

A mixture of 2.0 g. of 3,6-bis(4-chlorobutoxy) acridine hydrochloride and 150 ml. of diethylamine is heated in a steel bomb at 100° C. for 24 hours. The excess diethylamine is removed under reduced pressure. The residue is dissolved in 150 ml. of chloroform and this chloroform solution is washed with two 30 ml. portions of saturated aqueous sodium bicarbonate, then dried over sodium sulfate and filtered. The chlorofrom is evaporated and the residue is dissolved in 50 ml. of absolute ethanol. A 10 ml. portion of 6 N hydrochloric acid in isopropanol is added giving the desired product as yellow crystals.

후처리

  1. additionA mixture of 2.0 g
  2. customThe excess diethylamine is removed under reduced pressure
  3. dissolutionThe residue is dissolved in 150 ml
  4. washof chloroform and this chloroform solution is washed with two 30 ml
  5. dry with materialportions of saturated aqueous sodium bicarbonate, then dried over sodium sulfate
  6. filtrationfiltered
  7. customThe chlorofrom is evaporated
  8. dissolutionthe residue is dissolved in 50 ml
  9. additionportion of 6 N hydrochloric acid in isopropanol is added

출처 및 근거

ORD 기록
ord-a85676bb159f43a2a4936ca80286b5a0
출처 데이터셋
uspto-grants-1982_02
특허 번호
US04314061

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