참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|
| 반응물 | Sodium Hydroxide | HCID 14798 | — |
| 반응물 | Benzamide, N-cyano- | HCID 84805 | — |
| 반응물 | 2-Guanidino-4-(3-aminophenyl)-thiazole hydrochloride hydrobromide | HCID 178419579 | — |
| 용매 | Water | HCID 962 | — |
| 용매 | Dimethylformamide | HCID 6228 | — |
| 생성물 | HCID 178512618 | HCID 178512618 | — |
반응 단계
A mixture of 2-guanidino-4-(3-aminophenyl)-thiazole hydrochloride hydrobromide (1.2 g.) and benzoylcyanamide (0.7 g.) in dimethylformamide (15 ml.) and water (10 ml.) was heated at 90° C. for 2 hours. The mixture was diluted with water (30 ml.) and made strongly basic with dilute sodium hydroxide solution. The mixture was extracted with ethyl acetate (2×50 ml.) and the extract evaporated to dryness to give 2-guanidino-4-[3-(2-benzoylguanidino)phenyl]-thiazole as a dark gum (0.9 g.)
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| 특허 번호 | US04315009 |
|---|
| 출처 데이터셋 | uspto-grants-1982_02 |
|---|
| ORD ID | ord-6402d85af84c481a80d03f3996c0daa0 |
|---|
| 출처 메모 | uspto-grants-1982_02 |
|---|
