2-Bromo-1-(3-nitrophenyl)ethan-1-one → 2-hydroxy-1-(3-nitrophenyl)-1-ethanone

HRID 1446991노트

반응식

HRID 1446991 반응식
[N+:1]([C:4]1[CH:5]=[C:6]([CH:11]=[CH:12][CH:13]=1)[C:7](=[O:10])[CH2:8]Br)([O-:3])=[O:2].C([O-])(=[O:16])C.[Na+]>C(O)C>[N+:1]([C:4]1[CH:5]=[C:6]([CH:11]=[CH:12][CH:13]=1)[C:7](=[O:10])[CH2:8][OH:16])([O-:3])=[O:2]

참가 물질

4

반응물 2

HCID 752132-Bromo-1-(3-nitrophenyl)ethan-1-oneHCID 517045Sodium Acetate

생성물 1

HCID 27638542-hydroxy-1-(3-nitrophenyl)-1-ethanone

시약·촉매·용매 1

HCID 702Ethanol용매

실험 절차

Reaction of m-nitrophenacyl bromide with sodium acetate in ethanol gave m-nitrophenacyl alcohol. This was treated with dicyandiimide and HCl in aqueous methanol to give 2-guanidino4-(3-nitrophenyl)oxazole hydrochloride, m.p. 250°-251° C. The nitro residue was reduced with iron powder in acetic acid containing 10% v/v water to give 2-guanidino-4-(3-aminophenyl)oxazole.

출처 및 근거

ORD 기록
ord-76393fb21dc544dc81e2e90c203d7641
출처 데이터셋
uspto-grants-1982_02
특허 번호
US04315009

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