Formaldehyde → 1-Phenyl-4-(beta-morpholinopropionyl)-pyrazole hydrochloride

반응식

[C:1]1([N:7]2[CH:11]=[C:10]([C:12](=[O:14])[CH3:13])[CH:9]=[N:8]2)[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1.C=O.[ClH:17].[NH:18]1[CH2:23][CH2:22][O:21][CH2:20][CH2:19]1.[CH3:24]COCCO>>[ClH:17].[C:1]1([N:7]2[CH:11]=[C:10]([C:12](=[O:14])[CH2:13][CH2:24][N:18]3[CH2:23][CH2:22][O:21][CH2:20][CH2:19]3)[CH:9]=[N:8]2)[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1

참가 물질

반응물 4

HCID 712Formaldehyde

HCID 8076Glycol monoethyl ether

HCID 197884Morpholine, hydrochloride (1:1)

HCID 8229871-(1-phenyl-1H-pyrazol-4-yl)ethan-1-one

생성물 1

HCID 205505381-Phenyl-4-(beta-morpholinopropionyl)-pyrazole hydrochloride

반응 조건

온도: 5 °C

실험 절차

1-Phenyl-4-acetyl pyrazole (17.9 g) was mixed with paraformaldehyde (3.2 g), morpholine hydrochloride (11.71 g) and cellosolve (37 ml). The mixture was refluxed for 30 minutes and then cooled to 5° C. The white coloured Mannich Base was filted and washed with ethyl alcohol (100 ml) and acetone (50 ml). The white solid was dried at 70° C. to give 1-phenyl-4-(β-morpholinopropionyl)-pyrazole hydrochloride ##STR33## m.p. 212°-214° C.