Formaldehyde → 1-Phenyl-4-(beta-morpholinopropionyl)-pyrazole hydrochloride

HRID 1447297

반응식

HRID 1447297 반응식
[C:1]1([N:7]2[CH:11]=[C:10]([C:12](=[O:14])[CH3:13])[CH:9]=[N:8]2)[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1.C=O.[ClH:17].[NH:18]1[CH2:23][CH2:22][O:21][CH2:20][CH2:19]1.[CH3:24]COCCO>>[ClH:17].[C:1]1([N:7]2[CH:11]=[C:10]([C:12](=[O:14])[CH2:13][CH2:24][N:18]3[CH2:23][CH2:22][O:21][CH2:20][CH2:19]3)[CH:9]=[N:8]2)[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1

참가 물질

5

반응물 4

HCID 712FormaldehydeHCID 8076Glycol monoethyl etherHCID 197884Morpholine, hydrochloride (1:1)HCID 8229871-(1-phenyl-1H-pyrazol-4-yl)ethan-1-one

생성물 1

HCID 205505381-Phenyl-4-(beta-morpholinopropionyl)-pyrazole hydrochloride

반응 조건

온도
5 °C

실험 절차

1-Phenyl-4-acetyl pyrazole (17.9 g) was mixed with paraformaldehyde (3.2 g), morpholine hydrochloride (11.71 g) and cellosolve (37 ml). The mixture was refluxed for 30 minutes and then cooled to 5° C. The white coloured Mannich Base was filted and washed with ethyl alcohol (100 ml) and acetone (50 ml). The white solid was dried at 70° C. to give 1-phenyl-4-(β-morpholinopropionyl)-pyrazole hydrochloride ##STR33## m.p. 212°-214° C.

후처리

  1. temperatureThe mixture was refluxed for 30 minutes
  2. washwashed with ethyl alcohol (100 ml) and acetone (50 ml)
  3. customThe white solid was dried at 70° C.

출처 및 근거

ORD 기록
ord-dbf2e04fa6a14316901c5a9c2a043f8e
출처 데이터셋
uspto-grants-1982_02
특허 번호
US04316815

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