Acetic Acid → 1-(2-nitrobenzyl)-1H-pyrrole
반응식
[N+:1]([C:4]1[CH:11]=[CH:10][CH:9]=[CH:8][C:5]=1[CH2:6][NH2:7])([O-:3])=[O:2].CO[CH:14]1[CH2:18][CH2:17][CH:16](OC)O1.C(O)(=O)C>O>[N+:1]([C:4]1[CH:11]=[CH:10][CH:9]=[CH:8][C:5]=1[CH2:6][N:7]1[CH:14]=[CH:18][CH:17]=[CH:16]1)([O-:3])=[O:2]참가 물질
5
실험 절차
The starting material is prepared as follows: The mixture of 3,078 g of o-nitrobenzylamine and 2,670 g of 2,5-dimethoxytetrahydrofuran is added rapidly to 10,000 ml of glacial acetic acid at 86° while stirring under nitrogen. The mixture is stirred at 95° for 1.25 hours, cooled to 25° and combined with 30,000 ml of water. It is extracted with ethyl acetate, the extract is washed with 10% aqueous sodium hydroxide and 10% aqueous sodium chloride, filtered and evaporated to yield the 1-(o-nitrobenzyl)-pyrrole.
후처리
- customThe starting material is prepared
- stirringThe mixture is stirred at 95° for 1.25 hours
- temperaturecooled to 25°
- extractionIt is extracted with ethyl acetate
- washthe extract is washed with 10% aqueous sodium hydroxide and 10% aqueous sodium chloride
- filtrationfiltered
- customevaporated
출처 및 근거
- ORD 기록
- ord-e992fb8e8999490195b0aaaf80f95508
- 출처 데이터셋
- uspto-grants-1982_02
- 특허 번호
- US04316900
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