Sodium Carbonate → 1-(3-acetylthio-1-oxopropyl)-cis-4-methoxy-L-proline

반응식

[CH3:1][O:2][C@@H:3]1[CH2:7][NH:6][C@H:5]([C:8]([OH:10])=[O:9])[CH2:4]1.[C:11]([S:14][CH2:15][CH2:16][CH2:17]Cl)(=[O:13])[CH3:12].C(=O)([O-])[O-:20].[Na+].[Na+]>>[C:11]([S:14][CH2:15][CH2:16][C:17]([N:6]1[CH2:7][C@@H:3]([O:2][CH3:1])[CH2:4][C@H:5]1[C:8]([OH:10])=[O:9])=[O:20])(=[O:13])[CH3:12]

참가 물질

반응물 3

HCID 10340Sodium Carbonate

HCID 830443-Chloropropyl thioacetate

HCID 12849452(2S,4S)-4-methoxypyrrolidine-2-carboxylic acid2회

생성물 1

HCID 228193741-(3-acetylthio-1-oxopropyl)-cis-4-methoxy-L-proline

실험 절차

Following the procedure of Example 1 (d), cis-4-methoxy-L-proline is treated with a solution of 3-acetylthiopropyl chloride in the presence of sodium carbonate to yield 1-(3-acetylthio-1-oxopropyl)-cis-4-methoxy-L-proline.

출처 및 근거

ORD 기록: ord-a9ac93956cc14db980a458a1e84a433c
출처 데이터셋: uspto-grants-1982_02
DOI: 10.6084/m9.figshare.5104873.v1
특허 번호: US04316906

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