Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Ethanol → 7-[3-(Trifluoromethyl)phenyl]pyrazolo[1,5-a]pyrimidine-3-carbonitrile
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Ethanol | HCID 702 | — |
| 반응물 | 3-Hydroxy-3'-(trifluoromethyl)acrylophenone acetate | HCID 70477828 | — |
| 반응물 | HCID 178510443 | HCID 178510443 | — |
| 용매 | Dichloromethane | HCID 6344 | — |
| 생성물 | 7-[3-(Trifluoromethyl)phenyl]pyrazolo[1,5-a]pyrimidine-3-carbonitrile | HCID 2741014 | — |
반응 단계
A solution of 0.54 g. of 3-aminopyrazole-4-carbonitrile and 1.29 g. of 3-hydroxy-3'-(trifluoromethyl)acrylophenone acetate in 25 ml. of absolute ethanol is refluxed for 15 hours. The mixture is cooled and filtered giving a solid which is dissolved in methylene chloride and treated as described in Example 1, giving the desired product, m.p. 141°-142.5° C.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US04178449 |
| 출처 데이터셋 | uspto-grants-1979_12 |
| ORD ID | ord-a736a5ca521844769a26308750dad5c6 |
| 출처 메모 | uspto-grants-1979_12 |