3-(Dimethylamino)-1-phenyl-2-propen-1-one → 7-Phenylpyrazolo[1,5-a]pyrimidine-3-carboxylic acid ethyl ester

HRID 1447850

반응식

HRID 1447850 반응식
C[N:2]([CH3:13])[CH:3]=[CH:4][C:5]([C:7]1[CH:12]=[CH:11][CH:10]=[CH:9][CH:8]=1)=O.N[C:15]1[C:19]([C:20]([O:22][CH2:23][CH3:24])=[O:21])=C[NH:17][N:16]=1>C(O)(=O)C>[CH2:23]([O:22][C:20]([C:19]1[CH:15]=[N:16][N:17]2[C:5]([C:7]3[CH:8]=[CH:9][CH:10]=[CH:11][CH:12]=3)=[CH:4][CH:3]=[N:2][C:13]=12)=[O:21])[CH3:24]

참가 물질

4

반응물 2

HCID 3534603-(Dimethylamino)-1-phenyl-2-propen-1-oneHCID 178469928HCID 178469928, 화합물

생성물 1

HCID 112309367-Phenylpyrazolo[1,5-a]pyrimidine-3-carboxylic acid ethyl ester

시약·촉매·용매 1

HCID 176Acetic Acid용매

실험 절차

A mixture of 17.5 g. of 3-dimethylaminoacrylophenone and 15.52 g. of 3-amino-4-carbethoxypyrazole in 50 ml. of glacial acetic acid is refluxed for 4 hours and then evaporated. The residue is treated as described in Example 1, giving the desired product, m.p. 129°-130° C.

후처리

  1. additionA mixture of 17.5 g
  2. customevaporated
  3. additionThe residue is treated

출처 및 근거

ORD 기록
ord-4256e9932c594c8ea7c25bd641bd4b86
출처 데이터셋
uspto-grants-1979_12
특허 번호
US04178449

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