Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Acetic Acid → 3-Cyano-7-(alpha,alpha,alpha-trifluoro-m-tolyl)pyrazolo[1,5-a]pyrimidine-2-carboxamide
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Acetic Acid | HCID 176 | — |
| 반응물 | 3-amino-1H-pyrazole-4,5-dicarbonitrile | HCID 338830 | — |
| 반응물 | 3-Dimethylamino-3'-trifluoromethylacrylophenone | HCID 730024 | — |
| 생성물 | 3-Cyano-7-(alpha,alpha,alpha-trifluoro-m-tolyl)pyrazolo[1,5-a]pyrimidine-2-carboxamide | HCID 23329828 | — |
반응 단계
A mixture of 4.86 g. of 3-dimethylamino-3'-(trifluoromethyl)acrylophenone, 50 ml. of glacial acetic acid and 2.66 g. of 3-aminopyrazole-4,5-dicarbonitrile is refluxed for 16 hours and then evaporated. The residue is treated as described in Example 1, giving the desired product, m.p. 236°-238° C.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US04178449 |
| 출처 데이터셋 | uspto-grants-1979_12 |
| ORD ID | ord-81d27f0f6e7044e882a5a5e7bd1e9e35 |
| 출처 메모 | uspto-grants-1979_12 |