Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
3-amino-1H-pyrazole-4,5-dicarbonitrile → 3-Cyano-7-(alpha,alpha,alpha-trifluoro-m-tolyl)pyrazolo-[1,5-a]pyrimidine-2-carbonitrile
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | 3-amino-1H-pyrazole-4,5-dicarbonitrile | HCID 338830 | — |
| 반응물 | 3-Dimethylamino-3'-trifluoromethylacrylophenone | HCID 730024 | — |
| 용매 | Acetic Acid | HCID 176 | — |
| 생성물 | 3-Cyano-7-(alpha,alpha,alpha-trifluoro-m-tolyl)pyrazolo-[1,5-a]pyrimidine-2-carbonitrile | HCID 11370400 | — |
반응 단계
A mixture of 4.86 g. of 3-dimethylamino-3'-(trifluoromethyl)acrylophenone, 50 ml. of glacial acetic acid and 2.66 g. of 3-aminopyrazole-4,5-dicarbonitrile is refluxed for 10 hours and the solvent removed under reduced pressure. The residue is treated with trifluoroacetic anhydride to give the product of the example. cl EXAMPLE 44
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US04178449 |
| 출처 데이터셋 | uspto-grants-1979_12 |
| ORD ID | ord-3be5e32ab22c44608da2087ba1faac10 |
| 출처 메모 | uspto-grants-1979_12 |