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Ethylene Glycol → alpha-Isopropyl-4-trifluoromethoxyphenylacetic acid

HRID 1447919
노트
인쇄 미리보기

반응식

HRID 1447919 반응식
[CH:1]([CH:4]([C:7]1[CH:12]=[CH:11][C:10]([O:13][C:14]([F:17])([F:16])[F:15])=[CH:9][CH:8]=1)[C:5]#N)([CH3:3])[CH3:2].[OH-:18].[K+].C(O)C[OH:22]>O>[CH:1]([CH:4]([C:7]1[CH:12]=[CH:11][C:10]([O:13][C:14]([F:17])([F:16])[F:15])=[CH:9][CH:8]=1)[C:5]([OH:22])=[O:18])([CH3:3])[CH3:2]
참가 물질반응 조건실험 절차후처리출처 및 근거반응 노트

참가 물질

5

반응물 3

HCID 174Ethylene GlycolHCID 14797Potassium HydroxideHCID 20343265HCID 20343265, 화합물

생성물 1

HCID 20343284alpha-Isopropyl-4-trifluoromethoxyphenylacetic acid

시약·촉매·용매 1

HCID 962Water용매2회

반응 조건

온도
140 °C

실험 절차

A mixture of α-isopropyl-4-trifluoromethoxyphenylacetonitrile (2.0 g), potassium hydroxide (3.0 g) in ethylene glycol (35 ml) and water (3 ml) is heated at 140° C. for 8 hours. The solution is poured into water and extracted with ether (2×10 ml). The aqueous layer is acidified with dilute hydrochloric acid and extracted with ether (3×11 ml), washed with water (1×25 ml), dried (Na2SO4) and evaporated to an oil (1.23 g); IR (neat) 1700 cm-1.

후처리

  1. extractionextracted with ether (2×10 ml)
  2. extractionextracted with ether (3×11 ml)
  3. washwashed with water (1×25 ml)
  4. dry with materialdried (Na2SO4)
  5. customevaporated to an oil (1.23 g)

출처 및 근거

ORD 기록
ord-7eba90133f1040f68ef358be0c0d60ed
출처 데이터셋
uspto-grants-1979_12
DOI
10.6084/m9.figshare.5104873.v1
특허 번호
US04178460

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