Pyridine → m-Phenoxybenzyl alpha-isopropyl-4-trifluoromethoxyphenylacetate

HRID 1447921노트

반응식

HRID 1447921 반응식
[O:1]([C:8]1[CH:9]=[C:10]([CH:13]=[CH:14][CH:15]=1)[CH2:11][OH:12])[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.N1C=CC=CC=1.[CH:22]([CH:25]([C:29]1[CH:34]=[CH:33][C:32]([O:35][C:36]([F:39])([F:38])[F:37])=[CH:31][CH:30]=1)[C:26](Cl)=[O:27])([CH3:24])[CH3:23]>C(Cl)Cl>[CH:22]([CH:25]([C:29]1[CH:34]=[CH:33][C:32]([O:35][C:36]([F:37])([F:38])[F:39])=[CH:31][CH:30]=1)[C:26]([O:12][CH2:11][C:10]1[CH:13]=[CH:14][CH:15]=[C:8]([O:1][C:2]2[CH:3]=[CH:4][CH:5]=[CH:6][CH:7]=2)[CH:9]=1)=[O:27])([CH3:24])[CH3:23]

참가 물질

5

반응물 3

HCID 1049PyridineHCID 262953-Phenoxybenzyl alcoholHCID 20343288HCID 20343288, 화합물

생성물 1

HCID 20343285m-Phenoxybenzyl alpha-isopropyl-4-trifluoromethoxyphenylacetate

시약·촉매·용매 1

HCID 6344Dichloromethane용매2회

실험 절차

To a solution of m-phenoxybenzyl alcohol (1.89 g) and pyridine (1 ml) in methylene chloride (6 ml) is added a methylene chloride (7 ml) solution of α-isopropyl-4-trifluoromethoxyphenylacetyl chloride, prepared from the corresponding acid (2.46 g) as illustrated in Example 15. After stirring the reaction mixture overnight, it is washed with water, diluted hydrochloric acid solution, dilute potassium hydroxide solution, water and evaporated to an orange oil. Purification by silica gel chromatography gives the desired ester (2.76 g).

후처리

  1. washis washed with water, diluted hydrochloric acid solution, dilute potassium hydroxide solution, water
  2. customevaporated to an orange oil
  3. customPurification by silica gel chromatography

출처 및 근거

ORD 기록
ord-22765441f38e4e9d888cbf327b4ab857
출처 데이터셋
uspto-grants-1979_12
특허 번호
US04178460

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