Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Sodium Cyanide → 3-Fluoro-4-methoxyphenylacetonitrile
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Sodium Cyanide | HCID 8929 | — |
| 반응물 | Trihexylamine | HCID 66022 | — |
| 반응물 | 4-(Bromomethyl)-2-fluoro-1-methoxybenzene | HCID 2774553 | — |
| 용매 | Water | HCID 962 | — |
| 생성물 | 3-Fluoro-4-methoxyphenylacetonitrile | HCID 136251 | — |
반응 단계
A mixture of 4-(bromomethyl)-2-fluoroanisole (45.8 g, 0.21 mol), trihexylamine (1.4 g) and sodium cyanide (20.5 g, 0.42 mol) in water (50 ml) is heated at 60°-65° C. for 18 hours. The mixture is cooled and extracted in its ether, washed with water, saturated sodium chloride solution and dried (CNa2SO4). Evaporation of the solvent gives a solid, (33.2 g): m.p. 42°-46° C.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US04178460 |
| 출처 데이터셋 | uspto-grants-1979_12 |
| ORD ID | ord-0774a4ac458a4713bcbe32312b9f326f |
| 출처 메모 | uspto-grants-1979_12 |