참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|
| 반응물 | Nitric Acid | HCID 944 | — |
| 반응물 | 2-(4-Hydroxyphenyl)-3-methylbutyric acid | HCID 112192 | — |
| 용매 | Acetic Acid | HCID 176 | — |
| 생성물 | 2-(4-Hydroxy-3-nitrophenyl)-3-methylbutanoic acid | HCID 20343331 | — |
반응 단계
A mixture of α-isopropyl-4-hydroxyphenylacetic acid (18.2 g, 0.094 mol) in acetic acid (130 ml) is heated to 40° C. and nitric acid (70%, 9.56 g, 0.095 mol) is added at such a rate that the reaction temperature is maintained at 38°-40° and never exceeded 45° C. The reaction mixture is stirred at 40°-42° C. overnight and poured into ice-water. The yellow solid is collected by filtration, washed and dried (19.1 g); m.p. 103°-105°.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| 특허 번호 | US04178460 |
|---|
| 출처 데이터셋 | uspto-grants-1979_12 |
|---|
| ORD ID | ord-064d97781aa34826a40433985b9c75a6 |
|---|
| 출처 메모 | uspto-grants-1979_12 |
|---|
