Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
4-Chloro-2-fluorophenyl isocyanate → 3-Carbethoxy-4-(4-chloro-2-fluorophenylaminocarbonyl)thiomorpholine
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | 4-Chloro-2-fluorophenyl isocyanate | HCID 4558203 | — |
| 반응물 | Ethyl thiomorpholine-3-carboxylate | HCID 13604869 | — |
| 용매 | Diethyl Ether | HCID 3283 | — |
| 용매 | Hexane | HCID 8058 | — |
| 생성물 | 3-Carbethoxy-4-(4-chloro-2-fluorophenylaminocarbonyl)thiomorpholine | HCID 23343397 | 87.7% |
반응 단계
An emulsion of 14 g of 3-carbethoxythiomorpholine in 50 ml of n-hexane was added dropwise to a solution of 14 g of 4-chloro-2-fluorophenylisocyanate in 60 ml of anhydrous ether at 15° to 28° C. with stirring. A heavy oil formed after the addition. The oil crystallized after stirring at room temperature for 15 min. The precipitate was collected by filtration to give 24.3 g of 3-carbethoxy-4-(4-chloro-2-fluorophenylaminocarbonyl)thiomorpholine, m.p. 111.5°-112.5° C.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US04179276 |
| 출처 데이터셋 | uspto-grants-1979_12 |
| ORD ID | ord-5672a21d33ce40b3b7154d76b3ba6695 |
| 출처 메모 | uspto-grants-1979_12 |