참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|
| 반응물 | Iodine | HCID 807 | — |
| 반응물 | Sodium Hydroxide | HCID 14798 | — |
| 반응물 | 6-Ethyl-2-phenylpyrimidin-4(1H)-one | HCID 135629822 | — |
| 용매 | Water | HCID 962 | — |
| 생성물 | 6-ethyl-5-iodo-2-phenyl-4(3H)-pyrimidinone | HCID 135837532 | 94.5% |
반응 단계
A mixture of 8.18 g (40.9 mmol) of 6-ethyl-2-phenyl-4(3H)-pyrimidinone, 1.68 g (42.0 mmol) of sodium hydroxide, 10.42 g (41.0 mmol) of iodine and 50 mL of water was heated at 50° C. for 4 h. The mixture was cooled and filtered. The white solid collected was dried in a vacuum oven to leave 12.60 g (75%) of 6-ethyl-5-iodo-2-phenyl-4(3H)-pyrimidinone. 1 H-NMR (d6-DMSO) δ 1.25(3H,t), 2.85(2H,q), 7.50(3H,m), 8.15(2H,m).
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| 특허 번호 | US05726124 |
|---|
| 출처 데이터셋 | uspto-grants-1998_03 |
|---|
| ORD ID | ord-be4d8163d3b146d0a463a6fc363aaeaa |
|---|
| 출처 메모 | uspto-grants-1998_03 |
|---|
