3-Amino-4-(propylamino)benzoic acid → 2-Methyl-1-propyl-1,3-benzodiazole-5-carboxylic acid

HRID 1448088노트

반응식

HRID 1448088 반응식
[NH2:1][C:2]1[CH:3]=[C:4]([CH:8]=[CH:9][C:10]=1[NH:11][CH2:12][CH2:13][CH3:14])[C:5]([OH:7])=[O:6].Cl.[CH2:16](C(=N)OCC)[CH3:17]>C(O)(=O)C>[CH3:16][C:17]1[N:11]([CH2:12][CH2:13][CH3:14])[C:10]2[CH:9]=[CH:8][C:4]([C:5]([OH:7])=[O:6])=[CH:3][C:2]=2[N:1]=1

참가 물질

4

반응물 2

HCID 115864403-Amino-4-(propylamino)benzoic acidHCID 13000588Ethyl propanecarboximidate hydrochloride

생성물 1

HCID 202988562-Methyl-1-propyl-1,3-benzodiazole-5-carboxylic acid

시약·촉매·용매 1

HCID 176Acetic Acid용매

실험 절차

A mixture of 4.5 parts of 3-amino-4-(propylamino)benzoic acid, 2.6 parts of ethyl ethanecarboximidate hydrochloride and 50 parts of acetic acid is stirred first for 20 minutes at room temperature and further for 10 minutes at reflux. The reaction mixture is evaporated. The residue is crystallized from 2-propanol. The product is filtered off, washed with water and 2-propanol and dried, yielding 1.8 parts of 2-methyl-1-propyl-1H-benzimidazole-5-carboxylic acid; mp. >260° C.

후처리

  1. temperatureat reflux
  2. customThe reaction mixture is evaporated
  3. customThe residue is crystallized from 2-propanol
  4. filtrationThe product is filtered off
  5. washwashed with water and 2-propanol
  6. customdried

출처 및 근거

ORD 기록
ord-a5d7690b7d704eac937afc9326c9fb9b
출처 데이터셋
uspto-grants-1979_12
특허 번호
US04179505

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