Thionyl Chloride → (3,5-Dichloro-6-fluoro-2-pyridyloxy)acetyl chloride

HRID 1448412노트

반응식

HRID 1448412 반응식
[Cl:1][C:2]1[C:3]([O:10][CH2:11][C:12]([OH:14])=O)=[N:4][C:5]([F:9])=[C:6]([Cl:8])[CH:7]=1.S(Cl)([Cl:17])=O>>[Cl:1][C:2]1[C:3]([O:10][CH2:11][C:12]([Cl:17])=[O:14])=[N:4][C:5]([F:9])=[C:6]([Cl:8])[CH:7]=1

참가 물질

3

반응물 2

HCID 24386Thionyl ChlorideHCID 20379575(3,5-Dichloro-6-fluoro-2-pyridyloxy) acetic acid

생성물 1

HCID 20379628(3,5-Dichloro-6-fluoro-2-pyridyloxy)acetyl chloride

실험 절차

A solution was prepared by admixing 8.6 grams (0.036 mole) of 3,5-dichloro-6-fluoro-2-pyridyloxy acetic acid in 15 milliliters of thionyl chloride. The mixture was refluxed for about 50 minutes. At the completion of the reaction, the excess thionyl chloride was removed by distillation. The liquid residue was cooled and the crystals which formed were separated. The (3,5-dichloro-6-fluoro-2-pyridyloxy)acetyl chloride product was recovered in a yield of 8.4 grams (92 percent of theoretical). Upon analysis, the product was found to have carbon, hydrogen, chlorine and nitrogen contents of 32.9, 0.9, 41.9 and 5.3 percent, respectively as compared with the theoretical contents of 32.8, 0.4, 41.4 and 5.5 percent, respectively, as calculated for the above-named compound.

후처리

  1. customA solution was prepared
  2. temperatureThe mixture was refluxed for about 50 minutes
  3. customAt the completion of the reaction
  4. customthe excess thionyl chloride was removed by distillation
  5. temperatureThe liquid residue was cooled
  6. customthe crystals which formed
  7. customwere separated
  8. customThe (3,5-dichloro-6-fluoro-2-pyridyloxy)acetyl chloride product was recovered in a yield of 8.4 grams (92 percent of theoretical)

출처 및 근거

ORD 기록
ord-85ed653cad734f2d98f19c449b25a007
출처 데이터셋
uspto-grants-1979_12
특허 번호
US04180395

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