4-Amidinobenzamide Hydrochloride → HCID 15564073, 화합물

HRID 1448435노트

반응식

HRID 1448435 반응식
[CH2:1]([C:5]1[CH:10]=[CH:9][C:8]([C:11](=[CH:14]OCC)[CH:12]=O)=[CH:7][CH:6]=1)[CH2:2][CH2:3][CH3:4].Cl.[C:19]([C:22]1[CH:30]=[CH:29][C:25]([C:26]([NH2:28])=[O:27])=[CH:24][CH:23]=1)(=[NH:21])[NH2:20].C[O-].[Na+]>CO>[CH2:1]([C:5]1[CH:6]=[CH:7][C:8]([C:11]2[CH:12]=[N:20][C:19]([C:22]3[CH:30]=[CH:29][C:25]([C:26]([NH2:28])=[O:27])=[CH:24][CH:23]=3)=[N:21][CH:14]=2)=[CH:9][CH:10]=1)[CH2:2][CH2:3][CH3:4]

참가 물질

5

반응물 3

HCID 27242934-Amidinobenzamide HydrochlorideHCID 10942334Sodium MethoxideHCID 540230723-Ethoxy-2-(p-butylphenyl)acrolein

생성물 1

HCID 15564073HCID 15564073, 화합물

시약·촉매·용매 1

HCID 887Methanol용매

실험 절차

74.2 G. of 2-(4-n-butylphenyl)-3-ethoxy-acrolein, 77.8 g. of the 4-amidinobenzoic acid amide hydrochloride described earlier and 0.546 mol of sodium methylate (obtained by dissolving 12.55 g. of sodium metal in methanol) are suspended in 2500 ml. of methanol and stirred overnight at room temperature under an atmosphere of nitrogen. The yellow suspension is subsequently removed by filtration, washed with a small amount of ethanol and suspended in 4 liters of ether for further purification. The suspension is washed with water and then filtered again. Sparingly soluble 4-[5-(4-n-butylphenyl)-2-pyrimidinyl] benzoic acid amide is obtained.

후처리

  1. customThe yellow suspension is subsequently removed by filtration
  2. washwashed with a small amount of ethanol
  3. customsuspended in 4 liters of ether for further purification
  4. washThe suspension is washed with water
  5. filtrationfiltered again

출처 및 근거

ORD 기록
ord-d84327ea13cf4aba93d4d44cf46a0040
출처 데이터셋
uspto-grants-1979_12
특허 번호
US04180475

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