Sodium Bicarbonate → 2-n-Heptylthio-4-hydroxycyclopent-2-en-1-one

HRID 1448634노트

반응식

HRID 1448634 반응식
[CH2:1]([S:8][C:9]1[C:10](=[O:21])[CH2:11][CH:12]([O:14]C2CCCCO2)[CH:13]=1)[CH2:2][CH2:3][CH2:4][CH2:5][CH2:6][CH3:7].C(=O)(O)[O-].[Na+].C1CCCCC1.C(OCC)(=O)C>C(O)(=O)C.O.O1CCCC1>[CH2:1]([S:8][C:9]1[C:10](=[O:21])[CH2:11][CH:12]([OH:14])[CH:13]=1)[CH2:2][CH2:3][CH2:4][CH2:5][CH2:6][CH3:7]

참가 물질

7

반응물 3

HCID 516892Sodium BicarbonateHCID 203803622-n-Heptylthio-4-tetrahydropyranyloxycyclopent-2-en-1-oneHCID 21867204Cyclohexane ethylacetate

생성물 1

HCID 203803872-n-Heptylthio-4-hydroxycyclopent-2-en-1-one수율 99.2%

시약·촉매·용매 3

HCID 176Acetic Acid용매2회HCID 962Water용매HCID 8028Tetrahydrofuran용매

실험 절차

2-n-Heptylthio-4-tetrahydropyranyloxycyclopent-2-en-1-one (80 mg) was dissolved in 5 ml of a mixture of acetic acid, water and tetrahydrofuran in a ratio of 3:1:1 and 2 ml of acetic acid, and the solution was allowed to stand at room temperature for 12 hours. The reaction mixture was neutralized with sodium bicarbonate, and extracted with ethyl acetate. The extract was treated by a customary procedure to afford 58 mg (95% yield) of 2-n-heptylthio-4-hydroxycyclopent-2-en-1-one having a single spot in thin-layer chromatography (cyclohexane/ethyl acetate=4/6). The product had the following characteristics.

후처리

  1. extractionextracted with ethyl acetate
  2. additionThe extract was treated by a customary procedure

출처 및 근거

ORD 기록
ord-5f0dfdb5ae0b429abecec7d8bcda2a1e
출처 데이터셋
uspto-grants-1979_12
특허 번호
US04180672

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