3,4,5-Trimethoxybenzaldehyde → F1386-0126

HRID 1448950노트

반응식

HRID 1448950 반응식
[CH3:1][O:2][C:3]1[CH:4]=[C:5]([CH:8]=[C:9]([O:13][CH3:14])[C:10]=1[O:11][CH3:12])[CH:6]=O.[N:15]1([CH2:20][CH2:21][NH2:22])[CH:19]=[CH:18][CH:17]=[CH:16]1>C(O)(=O)C>[CH3:1][O:2][C:3]1[CH:4]=[C:5]([CH:6]2[NH:22][CH2:21][CH2:20][N:15]3[CH:19]=[CH:18][CH:17]=[C:16]23)[CH:8]=[C:9]([O:13][CH3:14])[C:10]=1[O:11][CH3:12]

참가 물질

4

반응물 2

HCID 68583,4,5-TrimethoxybenzaldehydeHCID 27638162-(1H-pyrrol-1-yl)-1-ethanamine

생성물 1

HCID 2770921F1386-0126수율 62.5%

시약·촉매·용매 1

HCID 176Acetic Acid용매

실험 절차

A solution of 3,4,5-trimethoxybenzaldehyde (19.6 g) and 2-(1H-pyrrol-1-yl)ethanamine (11 g, described in Example 7) in acetic acid (250 ml) is stirred at room temperature for 48 hr and evaporated under reduced pressure. The residue is partitioned between chloroform and 10% sodium carbonate and the organic phase is separated, washed with water, dried over magnesium sulfate, filtered and evaporated to give 18 g of the title compound, nmr(CDCl3) δ (2.40(s), 3.35(m), 3.84(s), 3.92(m), 5.03(s), 5.65(m), 6.12(t), 6.61(m) and 6.70(s).

후처리

  1. customevaporated under reduced pressure
  2. customThe residue is partitioned between chloroform and 10% sodium carbonate
  3. customthe organic phase is separated
  4. washwashed with water
  5. dry with materialdried over magnesium sulfate
  6. filtrationfiltered
  7. customevaporated

출처 및 근거

ORD 기록
ord-334fae9734624822bb34095114d10e37
출처 데이터셋
uspto-grants-1980_02
특허 번호
US04188389

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