3-Nitrobenzaldehyde → 2-Acetoxymethyl-6-methyl-4-(3'-nitrophenyl)-1,4-dihydropyridine-3,5-dicarboxylic acid diethyl ester

HRID 1449001노트

반응식

HRID 1449001 반응식
[N+:1]([C:4]1[CH:5]=[C:6]([CH:9]=[CH:10][CH:11]=1)[CH:7]=O)([O-:3])=[O:2].[CH2:12]([O:14][C:15](=[O:24])[CH2:16][C:17]([CH2:19][O:20][C:21](=[O:23])[CH3:22])=O)[CH3:13].[CH2:25]([O:27][C:28](=[O:33])/[CH:29]=[C:30](\[NH2:32])/[CH3:31])[CH3:26]>C(O)C>[CH2:12]([O:14][C:15]([C:16]1[CH:7]([C:6]2[CH:9]=[CH:10][CH:11]=[C:4]([N+:1]([O-:3])=[O:2])[CH:5]=2)[C:29]([C:28]([O:27][CH2:25][CH3:26])=[O:33])=[C:30]([CH3:31])[NH:32][C:17]=1[CH2:19][O:20][C:21](=[O:23])[CH3:22])=[O:24])[CH3:13]

참가 물질

5

반응물 3

HCID 74493-NitrobenzaldehydeHCID 6437562-Butenoic acid, 3-amino-, ethyl ester, (2Z)-HCID 11480907Ethyl 4-acetoxyacetoacetate

생성물 1

HCID 133883462-Acetoxymethyl-6-methyl-4-(3'-nitrophenyl)-1,4-dihydropyridine-3,5-dicarboxylic acid diethyl ester

시약·촉매·용매 1

HCID 702Ethanol용매

실험 절차

7.5 g of 3-nitrobenzaldehyde, 9.4 g of γ-acetoxyacetoacetic acid ethyl ester and 6.5 g of β-aminocrotonic acid ethyl ester in 40 ccs of ethanol are heated under reflux for 20 hours, the mixture is cooled and the precipitate is filtered off.

후처리

  1. temperatureunder reflux for 20 hours
  2. temperaturethe mixture is cooled
  3. filtrationthe precipitate is filtered off

출처 및 근거

ORD 기록
ord-6fecc888405549d1a07bffdb9dc092f3
출처 데이터셋
uspto-grants-1980_02
특허 번호
US04188395

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