참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|
| 반응물 | Acetic Acid | HCID 176 | — |
| 반응물 | O-Phenylenediamine | HCID 7243 | — |
| 반응물 | Benzonitrile, 3-ethyl- | HCID 96692 | — |
| 반응물 | Sodium Methoxide | HCID 10942334 | — |
| 용매 | Methanol | HCID 887 | — |
| 용매 | Water | HCID 962 | — |
| 생성물 | 2-(m-Ethylphenyl)benzimidazole | HCID 20347799 | — |
반응 단계
2.2 g. of o-phenylenediamine and 3.1 g. of m-ethylbenzonitrile were dissolved in 30 ml. of methanol. To the solution was added 1.1 g. of sodium methoxide in methanol. The mixture was stirred at 60° C. for 2 hours, acidified with acetic acid, stirred again at 100° C. for additional 3 hours and poured in 100 ml. of water. The resulting crystals were filtered off, dried and recrystallized from ethyl acetate. 2.7 g. of the product (60% of theory) was obtained. The product was identical to that obtained in Example 23.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| 특허 번호 | US04188486 |
|---|
| 출처 데이터셋 | uspto-grants-1980_02 |
|---|
| ORD ID | ord-9a49a61c1298479496cbdb29f4b4d733 |
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| 출처 메모 | uspto-grants-1980_02 |
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