Ethyl isocyanate → Ethyl-beta-ethylureido-beta-ethoxy acrylate

HRID 1449071노트

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HRID 1449071 반응식
[C:1]([O:5][O:6][C:7]([CH2:10][CH3:11])([NH2:9])[CH3:8])(=[O:4])[CH:2]=[CH2:3].[CH2:12]([N:14]=[C:15]=[O:16])[CH3:13]>C(#N)C>[C:1]([O:5][O:6][C:7]([CH2:10][CH3:11])([NH:9][C:15]([NH:14][CH2:12][CH3:13])=[O:16])[CH3:8])(=[O:4])[CH:2]=[CH2:3]

참가 물질

4

반응물 2

HCID 8022Ethyl isocyanateHCID 86736826Ethylbeta-amino-beta-ethoxy acrylate

생성물 1

HCID 86736827Ethyl-beta-ethylureido-beta-ethoxy acrylate수율 60.9%

시약·촉매·용매 1

HCID 6342Acetonitrile용매

실험 절차

To a solution of 15.9 g of ethyl-β-amino-β-ethoxy acrylate in 30 ml of acetonitrile was added 7.1 g of ethyl isocyanate, and the resulting mixture was allowed to stand at room temperature for one day and one night. The acetonitrile was distilled away under reduced pressure. To the residue was added 100 ml of ether and the system then dried over anhydrous sodium sulfate. The ether was distilled away and the residue was distilled under reduced pressure. Thus, 14 g of ethyl-β-ethylureido-β-ethoxy acrylate of a boiling point of 127° to 130° C. was obtained.

후처리

  1. distillationThe acetonitrile was distilled away under reduced pressure
  2. additionTo the residue was added 100 ml of ether
  3. dry with materialthe system then dried over anhydrous sodium sulfate
  4. distillationThe ether was distilled away
  5. distillationthe residue was distilled under reduced pressure

출처 및 근거

ORD 기록
ord-b7874db0e41f449080b95e1129020dc2
출처 데이터셋
uspto-grants-1980_02
특허 번호
US04188489

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