Phenyl isocyanate → Ethyl-beta-phenylureido-beta-ethoxy acrylate

HRID 1449072노트

반응식

HRID 1449072 반응식
[C:1]([O:5][O:6][C:7]([CH2:10][CH3:11])([NH2:9])[CH3:8])(=[O:4])[CH:2]=[CH2:3].[C:12]1([N:18]=[C:19]=[O:20])[CH:17]=[CH:16][CH:15]=[CH:14][CH:13]=1>C(#N)C>[C:1]([O:5][O:6][C:7]([CH2:10][CH3:11])([NH:9][C:19]([NH:18][C:12]1[CH:17]=[CH:16][CH:15]=[CH:14][CH:13]=1)=[O:20])[CH3:8])(=[O:4])[CH:2]=[CH2:3]

참가 물질

4

반응물 2

HCID 7672Phenyl isocyanateHCID 86736826Ethylbeta-amino-beta-ethoxy acrylate

생성물 1

HCID 86736828Ethyl-beta-phenylureido-beta-ethoxy acrylate수율 43.2%

시약·촉매·용매 1

HCID 6342Acetonitrile용매

실험 절차

Into a solution of 15.9 g of ethyl-β-amino-β-ethoxy acrylate in 30 ml of acetonitrile there was dropped 11.9 g of phenyl isocyanate while cooling, and the resulting mixture was allowed to stand at room temperature for 5 hours. The acetonitrile was then distilled away. To the residue was added 100 ml of ether, which was then dried over anhydrous sodium sulfate. The ether was distilled away and the residue obtained was distilled under reduced pressure. Thus, 12 g of ethyl-β-phenylureido-β-ethoxy acrylate of a boiling point of 83° to 84° C./0.5 mmHg was obtained.

후처리

  1. temperaturewhile cooling
  2. distillationThe acetonitrile was then distilled away
  3. additionTo the residue was added 100 ml of ether, which
  4. dry with materialwas then dried over anhydrous sodium sulfate
  5. distillationThe ether was distilled away
  6. customthe residue obtained
  7. distillationwas distilled under reduced pressure

출처 및 근거

ORD 기록
ord-b29fea7f74284a7ea5005b5f90590028
출처 데이터셋
uspto-grants-1980_02
특허 번호
US04188489

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