Tetrahydrofuran → 2-(4-Cinnamoylpiperazin-1-yl)-4-amino-6,7-dimethoxyquinazoline

HRID 1449157노트

반응식

HRID 1449157 반응식
O1CCCC1.Cl.[N:7]1([C:13]2[N:22]=[C:21]([NH2:23])[C:20]3[C:15](=[CH:16][C:17]([O:26][CH3:27])=[C:18]([O:24][CH3:25])[CH:19]=3)[N:14]=2)[CH2:12][CH2:11][NH:10][CH2:9][CH2:8]1.[C:28](Cl)(=[O:37])[CH:29]=[CH:30][C:31]1[CH:36]=[CH:35][CH:34]=[CH:33][CH:32]=1>C(N(CC)CC)C>[C:28]([N:10]1[CH2:11][CH2:12][N:7]([C:13]2[N:22]=[C:21]([NH2:23])[C:20]3[C:15](=[CH:16][C:17]([O:26][CH3:27])=[C:18]([O:24][CH3:25])[CH:19]=3)[N:14]=2)[CH2:8][CH2:9]1)(=[O:37])[CH:29]=[CH:30][C:31]1[CH:36]=[CH:35][CH:34]=[CH:33][CH:32]=1

참가 물질

5

반응물 3

HCID 8028TetrahydrofuranHCID 660233-Phenylprop-2-enoyl chlorideHCID 204738332-Piperazine-4-amino-6,7-dimethoxy quinoline hydrochloride

생성물 1

HCID 30540822-(4-Cinnamoylpiperazin-1-yl)-4-amino-6,7-dimethoxyquinazoline

시약·촉매·용매 1

HCID 8471Triethylamine용매

실험 절차

To 10 ml. of tetrahydrofuran were added 1.2 g. of 2-(piperazin-1-yl)-4-amino-6,7-dimethoxyquinazoline.hydrochloride and 1.33 g. of triethylamine and the resulting mixture was stirred for 30 minutes. Thereafter, 0.66 g. of cinnamoyl chloride was added thereto and the resulting mixture was stirred at room temperature overnight. The crystalline substance thus separated was recovered by filtration, washed thoroughly with water and ethanol and then dried to afford 0.66 g. of the desired product.

후처리

  1. customThe crystalline substance thus separated
  2. filtrationwas recovered by filtration
  3. washwashed thoroughly with water and ethanol
  4. customdried
  5. customto afford 0.66 g

출처 및 근거

ORD 기록
ord-4a7cd3c954d949618dde164126456979
출처 데이터셋
uspto-grants-1980_02
특허 번호
US04189484

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