Cyclopropylamine → HCID 771127, 화합물

HRID 1449393노트

반응식

HRID 1449393 반응식
[Cl:1][C:2]1[CH:3]=[C:4]([CH:10]=[CH:11][CH:12]=1)[CH:5]=[CH:6][C:7](Cl)=[O:8].[CH:13]1([NH2:16])[CH2:15][CH2:14]1>C1C=CC=CC=1>[Cl:1][C:2]1[CH:3]=[C:4]([CH:10]=[CH:11][CH:12]=1)/[CH:5]=[CH:6]/[C:7]([NH:16][CH:13]1[CH2:15][CH2:14]1)=[O:8]

참가 물질

4

반응물 2

HCID 69828CyclopropylamineHCID 53411290HCID 53411290, 화합물

생성물 1

HCID 771127HCID 771127, 화합물수율 75.6%

시약·촉매·용매 1

HCID 241Benzene용매

실험 절차

A solution of 3-chlorocinnamoyl chloride (6 g) in dry tolune (100 ml) was added with stirring to a solution of cyclopropylamine (6 g) in dry benzene (50 ml). The reaction mixture was allowed to stand at room temperature overnight, and the solvent was evaporated under reduced pressure. The residue was thoroughly triturated with water containing a small amount of sodium carbonate, washed with water and filtered. Recrystallization of the resulting crude product from ethanol-water (1:10) gave trans 3-chloro-N-cyclopropylcinnamamide (5 g), m.p. 112°-113° C. Elemented analysis, nmr and ir data were all consistent with the assigned structure. TLC gave one spot run on silica gel with 5:1 and with 3:1 hexane:ethanol.

후처리

  1. customthe solvent was evaporated under reduced pressure
  2. customThe residue was thoroughly triturated with water containing a small amount of sodium carbonate
  3. washwashed with water
  4. filtrationfiltered
  5. customRecrystallization of the resulting crude product from ethanol-water (1:10)

출처 및 근거

ORD 기록
ord-c3dc7821fa6a4f168a0ab82019f9f984
출처 데이터셋
uspto-grants-1980_02
특허 번호
US04190674

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