Sulfuric Acid → 4,6-dimethyl-1H-indole-2,3-dione
반응식
[OH:1]S(O)(=O)=O.[CH3:6][C:7]1[CH:8]=[C:9]([NH:14][C:15](=[O:19])[CH:16]=NO)[CH:10]=[C:11]([CH3:13])[CH:12]=1>O>[CH3:6][C:7]1[CH:12]=[C:11]([CH3:13])[CH:10]=[C:9]2[C:8]=1[C:16](=[O:1])[C:15](=[O:19])[NH:14]2참가 물질
4
반응 조건
- 온도
- 80 °C
실험 절차
To a stirred warm (60°-70° C.) solution of concentrated H2SO4 (60 mL) and water (6 mL) was added in small portions N-(3,5-dimethylphenyl)-2-(hydroxyimino)acetamide (15.0 g, 78 mM) so that the temperature of the reaction mixture did not exceed 70° C. After the addition was completed, the reaction mixture was heated at 80° C. for 10 min and then cooled and poured onto ice. The resulting mixture was filtered and the collected solids were washed with water and dried to provide the title compound (9.93 g, 72.6%); MS(CI): 176.
후처리
- customdid not exceed 70° C
- additionAfter the addition
- temperaturecooled
- additionpoured onto ice
- filtrationThe resulting mixture was filtered
- washthe collected solids were washed with water
- customdried
출처 및 근거
- ORD 기록
- ord-1ec850f6e05c48888403093976538546
- 출처 데이터셋
- uspto-grants-1997_02
- 특허 번호
- US05599814
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